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On average, patients using Semaglutide or Tirzepatide for 68 weeks without diet or exercise lost 15% (Semaglutide) and 20% (Tirzepatide) of their body weight in clinical studies
The GLP-1 fatigue guide and the GLP-1 headache guide provide broader context for these side effects across the entire class of incretin-based therapies, not just tirzepatide specifically
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