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Medicare Advantage plans must give you the same coverage as Original Medicare and should, therefore, cover B12 injections when medically necessary

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For example, if you're exploring the nuances of cellular energy metabolism, you might need the precise control offered by injections

They are prepared by licensed compounding pharmacies under physician prescription and have not been evaluated through clinical trials for safety, efficacy, or therapeutic equivalence to any FDA-approved medications

The higher cost includes more comprehensive care

Since this 2012 publication, there has been very little new research into this question