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This is the primary safety metric for the insulin resistance concern

Halawi H, Khemani D, Eckert D, et al

18:2300014 (2023) Lemos Jnior WJF, Gonalves IdM, Guedes JB, Deamici KM, Santos LO

10.1186/s13229-016-0088-6 25

Supplements should not be used to replace a healthy balanced diet and adequate physical exercise