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The medications have also been shown to reduce complications from kidney disease and even protect the brain

Reduced appetite, which is actually the intended pharmacological effect, is nearly universal but can feel intense initially

Fatty and fried foods, citrus fruits and juices, tomatoes and tomato-based products, chocolate, coffee, mint, and carbonated beverages are among the most consistent triggers

Two melanocortin receptors (MC3R and MC4R) are expressed in the brain, although both have been implicated in the regulation of energy balance, MC4R has a predominant role in the regulation of food intake (Adan et al., 2006)