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Senescent tumor cells secrete a TGF--enriched senescence-associated secretory phenotype (SASP), which activates AKT-mTOR signaling, reshapes the TME, and promotes malignant progression under therapeutic pressure
With these points in mind, we undertook a broad assessment of published clinical data, curating the body weight loss (% from baseline), glycosylated hemoglobin levels (HbA1c), and nausea responses (% patients reporting) from the SUSTAIN 3, SUSTAIN 7, SCALE Diabetes, SURPASS 2, and STEP 2 trials (64, 66, 67) ( Figures 1AC )
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When estrogen levels decline during menopause, every single one of these metabolic processes takes a hit
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