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QMP) in albumin reported to improve its pH-dependent binding to FcRn 11 , and found that this albumin engineering compensated for the decrease in receptor binding caused by L585 cleavage
10.1007/s00125-015-3608-6 41
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This sudden release can lead to suboptimal drug concentrations at the intended target site in the body, diminishing the drugs therapeutic effect [339]
That discrepancy is the core of the concern
has acted as consultant, advisory board member and speaker for Boehringer Ingelheim, Eli Lilly, Novo Nordisk and Sanofi, an advisory board member Lexicon, Pfizer, ShouTi Pharma Inc, AstraZeneca and Medtronic and as a speaker for AstraZeneca, Napp Pharmaceuticals, Novartis and Amgen
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