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Using CRISPR-Cas9 in human and mouse cells, genome-wide, targeted loss-of-function pooled screens have been studied that has provided information about the inactivated genomic loci and strategies that modulate transcriptional activities (Shalem et al., 2015)

However, the absorption of Se also depends on the content of protein, fat, heavy metals, and other compounds in the diet, and food preparation practices (55), and from the average diet, the Se absorption is approximately 7080% (45, 57)