When blood sugar improves quickly, the retinas diseased microvasculature may react in a way that temporarily worsens leakage, hemorrhage, or progression in some patients
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These are cases where both primary and side effects can clash with individual disorders and either become much worse than usual, or act against the way the medicines are supposed to
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These effects are dose-dependent and typically mild at the starting dose
However, despite the mounting evidence linking inflammation to T2DM and depression [208, 209], few studies have examined depressive symptoms in diabetes patients using anti-inflammatory agents