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These mutations alter the activity of the encoded enzymes such that instead of converting isocitrate to 2-oxoglutarate (-ketoglutarate), while also generating NADPH, the mutant IDH enzymes reduce 2-oxoglutarate (-ketoglutarate) to 2-hydroxyglutarate (2-HG) while simultaneously oxidizing NADPH to NAPD +

IGF-1 Protects Neurons in the Cortex and Subventricular Zone in a Periventricular [PMID: 33402478] Laboratory literature summary: IGF-1 Protects Neurons in the Cortex and Subventricular Zone in a Periventricular Leucomalacia Model

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Tablets Tablet development requires compression, disintegration, taste, odor and stability evaluation

Proc Natl Acad Sci 101:37803785

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