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Advantage of PAE over Surgery Less risk of sexual side effects, such as retrograde ejaculation Lower risk of incontinence Less likely to require urinary catheterization Less downtime with fast recovery Minimally invasive without large incisions Safe and effective alternative to surgery More than 3 out of 4 men avoid TURP surgery Can serve as a bridge between medical therapy and surgery Surgical options such as TURP and open prostatectomy have higher reported rates of retrograde ejaculation (ejaculation into the bladder rather than out through the urethra), impotence, and urinary incontinence

Ferretti G, Bacchetti T, Moroni C, Savino S, Liuzzi A, Balzola F et al

Note how many nights your sleep is disrupted by itching

Yoon G, Kim YK, Song J

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

DSIP appears to affect sleep depth and quality rather than timing