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Estradiol indirectly increases POMC activity through its effects on NPY/AgRP neurons (82, 83)
Rebosio C, Balbi M, Passalacqua M, Ricciarelli R, Fedele E (2018) Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus
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This approach not only enhances therapeutic efficacy but also reduces the risk of unwanted side effects (Zhong et al., 2016)
Hepatology 52 , 774788 (2010)
One study also found that discontinuation due to side effects was higher among those taking oral semaglutide compared to those taking injectable semaglutide
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