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Central Illustration Abstract Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have surged in popularity in recent years, with discussions about their on-label and off-label use spilling into the public forum

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It is particularly effective at reducing visceral fat, making it a valuable tool for improving body composition and combating fat accumulation around internal organs

However, the study states that for participants in "Protocol 2" (the group with an existing and active SUD), the majority of participants were taking SGLT-2 inhibitors (n=64 849) (like Jardiance)

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Conversely, when the body is too cold, it reduces blood flow to the skin and initiates shivering to generate heat