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One limitation of most PK and PD studies is the enrollment of healthy subjects, whereas the major target population for use of GLP1RAs are patients with diabetes and obesity who may have co-morbidities that might affect the PK results
Thats a pharmacokinetic reality oral peptide absorption is inherently less efficient
diabetes-related vaginal microbiome alterations are documented, particularly in peri/postmenopausal women
Chuong, V
For patients with comorbidities, including chronic inflammatory conditions, specialist input may be appropriate
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