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The CD44 targeting moiety, hyaluronic acid, was first functionalized with bone targeting molecule, alendronate and then coupled to DSPE-PEG-COOH through GSH-cleavable disulfide (-SS-) linker to obtain amphiphilic lipid architecture
In rat hepatocytes, metformin inhibits mitochondrial glycerophosphate dehydrogenase, reducing the conversion of cytosolic lactate into pyruvate [42]
The hydrophobic face of Exendin-4(9-39) is formed by residues such as Val19, Phe22, Ile23, Leu26, Ala18, Trp25, and Pro31 which form hydrophobic interactions with the GLP-1R
It also has many other functions in the body
Materials and Methods Materials GHK and GHK-Cu were purchased from McBiotec (Nanjing, China)
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