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In macrophage models, -KG promotes JMJD3-mediated H3K27me3 demethylation, thereby favoring the expression of M2-related genes, whereas succinate accumulation can inhibit demethylase activity and sustain a pro-inflammatory transcriptional state ( It should be noted that most current evidence regarding amino acid-mediated regulation of macrophage polarization is derived from in vitro cell models or animal experiments, whereas systematic validation in human clinical samples remains relatively limited
But specific situations call for different approaches
Ferroptosis is an oxidative, iron-dependent form of cell death that is distinct from apoptosis, classic necrosis, autophagy and other forms of cell death [5] (Table 1)
Elastin preserves the elasticity of the skin, supports the maintenance and normal functioning of the joints and surrounding tissues
doi: 10.3389/fphys.2024.1347459 93 BockmannJHKohsarMMurrayJMHamedVDandriMLthSet al
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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