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This observation leads to the question of whether supraphysiological stimulation (as occurs with GLP-1RA use) could accelerate the progression of PanIN lesions into PDAC
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Also, the variability in follow-up duration across the included RCTs can affect event capture rates and risk estimates, as shorter trials may underreport long-term outcomes while longer trials may reflect cumulative risks
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When paired with strength training and adequate protein, it does not appear to cause muscle loss
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