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Methods A literature search was conducted in the MEDLINE (via PubMed) and Web of Science databases from the inception up February 2020

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Genes were ranked based on the Pearson correlation coefficient ( R ) calculated between their basal log 2 (TPM + 1) expression and the PRISM log 2 (fold change) de-enrichment values from the 2 M dose across the cell lines

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The classical somatomedin hypothesis (Salmon and Daughaday, 1957, foundational sulfation factor research) assumed all peripheral IGF-1 came from this hepatic source

Emitted light was detected at 520 nm with a bandwidth of 10 nm