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Genes related to the Fenton reaction included those associated with the Warburg effect and proliferation, cytosolic iron-sulfur cluster synthesis, neutralization of HO, NADPH-dependent dehydrogenases, exogenous superoxide synthesis, cytosolic iron transporters, the proteasome, the oxidative-to-glycolytic shift, the Warburg effect, and central carbon metabolism in cancer obtained from KEGG database ( Other gene lists were custom-designed to capture broader biological processes and disease-relevant pathways

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2 Adverse events in PIONEER 4 (a head-to-head trial vs liraglutide 1.8 mg) 2 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Because clinical trials are conducted under widely varying conditions, AE rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 a Data are n (%)

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