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Efficacy and safety of glucagon-like peptide-1 receptor agonists for weight loss among adults without diabetes

Intriguingly, in other organ systems, SLGT2 inhibitors also appear to drive changes that are potentially relevant to skeletal muscle dysfunction, for example, increasing lipolysis and ketogenesis, reducing inflammatory cytokines in liver [153], the aforementioned reduction in RAAS activity [154] and upregulation of AMPK via the sestrin pathway with consequent inhibition of mTOR in cardiac myocytes [153]

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10.1210/jc.2011-0555 56 IwataN.HasegawaT.FujitaS.NagaoS.NakanoY.NadaT.et al (2018)

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