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Gut microbiome dysbiosis: an imbalance in the composition or function of the gut microbial community, often associated with altered transit time, dietary shifts, or inflammation
In our own study, 4-week metformin treatment also increased GLP-1R expression in pancreatic -cells in Goto-Kakizaki rats, a non-obese type 2 diabetes animal model [36]
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GLP-1RA may thus confer benefits when used in individuals with established cardiovascular disease (mainly on atherosclerotic basis) or chronic kidney disease who accept injections
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The appetite suppression becomes more noticeable, and food cravings often decrease substantially
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