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This large concentration difference means that there is an insurmountable concentration gradient that prevents extracellular glutathione from entering cells

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[3] For confirmed deficiency with neurological involvement: 1 mg IM on alternate days until no further improvement, then 1 mg every two months urgent initiation is essential to prevent irreversible nerve damage

RNF39 mediates K48-linked ubiquitination of DDX3X and inhibits RLR-dependent antiviral immunity