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1,2 FLOW: kidney outcomes study design 2,4,5 2,4,5 g Randomization was stratified according to SGLT-2i use at baseline

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Taken together, GCGR agonism offers a promising yet complex strategy in cardiometabolic disease, as it promotes weight loss and energy expenditure while also increasing blood glucose, underscoring the need for dual- and triple-agonist approaches (GLP1R/GIPR/GCGR) that balance metabolic and CV effects