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FDA-APPROVED INDICATIONS Type 2 diabetes As an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus Limitations of use: has not been studied in patients with a history of pancreatitis TYPE 2 DIABETES RCT SURPASS-2 trial - Tirzepatide vs Semaglutide in Patients with Type 2 Diabetes, NEJM (2021) [PubMed abstract] The SURPASS-2 trial enrolled 1879 adults with type 2 diabetes who were inadequately controlled with metformin at a dose of at least 1500 mg per day Main inclusion criteria Age 18 years T2DM uncontrolled with metformin at 1500 mg/day A1C of 7 - 10.5% BMI 25 and stable for 3 months Main exclusion criteria Type 1 diabetes GFR 50 ng/L

Introduction Mycotoxins are biologically active compounds capable of disrupting cellular membranes, impairing mitochondrial function, and altering immune signaling

Research shows levels decline alongside oestrogen, making targeted support particularly relevant during midlife

In accordance with previous reports 36,37 , our GSEA analysis revealed positive enrichment for genes of the mTORC1 signaling pathway in Gclc -sufficient MZB compared to FoB (Fig

(the "Gold Book") (2025)

doi: 10.1126/science.272.5267.1492 138 JeanS.JuneauR