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A more recent study also confirms that some zonulin ELISA kits are not specific and that increased blood zonulin levels in patients with IBS are not associated with colonic paracellular permeability assessed in Ussing chambers (75)

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Probiotics have been shown to improve the absorption of thyroid medication and to reduce fatigue in hypothyroid patients [15]

However the median baseline TPO-antibody concentrations in the women were much lower than in the earlier study, the selenium dose was less than one third as high (60 g/d) and the trial was not adequately powered ( Reference Mao, Pop and Bath 98 )