The GLP-1 gut motility paradox: why some get constipation and others get diarrhea Here's the pattern that confuses patients: in the STEP 1 trial, 23.7% of semaglutide patients reported constipation, but 8.2% reported diarrhea
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Nakandakari-Higa, S
J Biol Chem 229(1):189197 Mittova V, Theodoulou FL, Kiddle G, Gmez L, Volokita M, Tal M, Foyer CH, Guy M (2003) Coordinate induction of glutathione biosynthesis and glutathione-metabolizing enzymes is correlated with salt tolerance in tomato
Glucagon-like peptide 1 (GLP-1) is a hormone that triggers the release of insulin, inhibits the secretion of glucagon to prevent blood sugar levels rising, slows the emptying of the stomach and increases satiety
These symptoms could indicate pancreatitis, gastroparesis, or other serious conditions that require evaluation and may necessitate stopping the medication temporarily