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If the deficiency is detected, metformin can be continued while the deficiency is corrected with B 12 supplements

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These findings have positioned FOXO4-DRI as one of the most mechanistically specific senolytic peptides currently available for research purposes, distinguishing it from small-molecule senolytics that operate through broader cellular pathways

However, the metabolism of phenytoin may be saturated based on its zero-order kinetics, so phenytoin metabolism cannot increase any higher