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You give the shots just under the skin in the abdomen or outer thigh.* Potential benefits of GLP-1 medications beyond weight loss include: Lowering blood pressure Improving lipid disorders Lowering your risk for heart disease Lowering your risk for kidney disease Possible side effects of GLP-1 medications include: Loss of appetite Nausea Vomiting Diarrhea Headaches Indigestion Rare but severe side effects include: Pancreatitis Medullary Thyroid Cancer Allergic Reactions Low Blood Sugar *You should not take GLP-1 agonists if you have a history of pancreatitis, Thyroid Cancer or a family history of Multiple Endocrine Neoplasia or Thyroid Cancer

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With respect to body weight, semaglutide OW was associated with a significant weight loss benefit (mean difference 0.75 kg

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