The distinction sounds academic until you consider what it means for appetite suppression, muscle preservation, metabolic adaptation, and long-term outcomes
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Macklin PS, Morris PJ, Knight SR
However, clinical trials have shown that intranasal delivery systems do not deliver detectable levels of peptides within the blood
We used a Mendelian randomization design to test whether this relation might be causal
Some peptides haven't been thoroughly tested, but they're considered generally safe.