For most licensed weight loss medicines, menstrual changes are not a direct pharmacological effect of the drug itself, but rather a secondary consequence of significant or rapid weight loss and the associated changes in energy availability and body composition
While ROS helps fight infection, high levels of oxidative stress can damage cells and lead to neuroinflammation
Control of proliferation and differentiation of ovine granulosa cells by insulin-like growth factor-I and follicle-stimulating hormone in vitro
Ponath, G., Park, C
The four test groups received 0.05 mg/kg, 0.12 mg/kg, 0.23 mg/kg, and 0.7 mg/kg oral semaglutide in 0.1 mL DW, whereas the control group received only 0.5 mL DW
Note: animal studies indicate that high doses of DPP-4 inhibitors & GLP-1 agonists cause expansion of cells of the pancreatic ductal glands and can cause premalignant pancreatic intraepithelial lesions (PanIN) that have the potential to progress to pancreatic adenocarcinoma