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Bottom line: Exercise improves nearly every marker of health even when the scale barely moves

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Ozempic can cause gastrointestinal side effects, but they are not as prevalent with Ozempic as with metformin

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Glucagon receptor-mediated effects introduce additional considerations: Potential for transient increases in heart rate (also observed with GLP-1R agonists) Theoretical risk of hyperglycaemia from glucagon signalling, though phase 2 trial data suggest this is counterbalanced by concurrent GLP-1R and GIPR agonism In phase 2 trials, the most commonly reported adverse events were gastrointestinal in nature, consistent with the class

When to Seek Help for Persistent GERD on GLP-1 Therapy Mild heartburn or occasional acid reflux during the first few weeks of GLP-1 therapy often resolves spontaneously as your GI tract adjusts