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For example, ritonavir acts as an inhibitor of CYP3A4/5 (ref
76 GST prodrugs appear to have a more favorable adverse-event profile, given that they are ingested as an inactive compound and undergo breakdown to release cytotoxic metabolites only in the presence of high concentrations of enzymes that occur in the proximity of tumor cells, thereby reducing collateral damage to healthy cells
doi: 10.1056/NEJMoa2301972 14 GarveyWTBlherMOsorto ContrerasCKDaviesMJWinning LehmannEPietilinenKHet al
Duration and Dosage of Medication : Longer-term use and higher doses might increase the likelihood of side effects
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