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A common research-planning SubQ start is 50 mg (about 0.50 mL at 100 mg/mL) once weekly or three times weekly, then escalate by ~25 mg as tolerated
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Animal toxicology studies found no acute toxicity, organ damage, or reproductive toxicity across multiple routes and doses, but these studies lasted only up to 6 weeks
This bypasses the digestive system, making injections especially effective for individuals with absorption challenges
It's recommended that all women who could get pregnant should take a daily supplement of folic acid
While some patients tolerate treatment well when appropriately evaluated, safety depends on individual health status, medications, and clinical judgment
