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Spironolactone also increases the concentration of lithium (for bipolar disorder) and digoxin (for heart problems), raising the risk of side effects from those drugs
Overdosing increases side effects without proportional benefit
Treatment is preceded by a bowel preparation protocol that may include antibiotics
The distinction between irritation and allergy matters enormously here
Neither medication is universally "better," and anyone who tells you otherwise is selling something
4.3 (Caliper Life Sciences, USA) software was used to access the images and acquire the data
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