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Even people who get their B12 from animal-based products can still have difficulty absorbing B12
Rarely reported symptoms associated with excessive B12 intake may include: Skin reactions : Acne-like eruptions or rosacea-type dermatitis have been occasionally reported, particularly with high-dose intramuscular injections Gastrointestinal disturbance : Mild nausea, diarrhoea, or abdominal discomfort, though these are uncommon Headache : Infrequent reports of headaches following parenteral B12 administration Hypersensitivity reactions : In very rare cases, allergic reactions to injectable B12 preparations have been documented It is crucial to note that there is no established link between standard B12 supplementation and serious adverse effects
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Hydroxocobalamin has a long safety record, no meaningful overdose risk because excess is excreted in urine, and a very low rate of allergic reactions
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In a systematic review, researchers found inadequate evidence to determine if intravenous vitamin C was beneficial for cancer treatment
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