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[1] [2] Because the drug is not yet licensed, all information regarding its side effects, including long-term risks, is derived from clinical trial data rather than post-marketing surveillance

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PMID 16953016

We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis