SURMOUNT-3 (N=579), which enrolled patients who had already completed a 12-week intensive lifestyle run-in, showed 18.4% additional weight loss with tirzepatide on top of lifestyle modification [23]
Influencing factors and transformation dilemmas of GLP-1RAs skeletal muscle efficacy differences The reasons for this difference in efficacy are complex, mainly involving two key dimensions: the dose effect of the drug and the baseline status of the patients
Using nuclear magnetic resonance (NMR) spectroscopy, Smeland and colleagues also demonstrated increased levels of norepinephrine and serotonin in the cortex of healthy mice, after 25 days of treatment with acetylcarnitine at a daily dose of approximately 0.5 g/kg body weight [117]
That doesnt mean it hasnt happened, I have just not observed it
J Diabetes (2019) 11(7):50918
How often do I need to take Ozempic as a GLP-1 receptor agonist for weight loss