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Some patients experience minimal gastrointestinal upset, whilst others find nausea and vomiting substantially affect their quality of life
Source data ( n , LSM, s.e.) for Extended Data Fig
Nausea usually peaks within 24 hours of injection and often improves by the following day
The dual receptor mechanism also appears to produce somewhat different gastrointestinal tolerability compared to single-receptor drugs
The peptide is now in an aqueous environment, making it far more susceptible to hydrolysis and other forms of chemical degradation
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