While there have been isolated reports of mood changes or depressive symptoms in some individuals, these cases are rare and often involve patients with pre-existing psychiatric conditions. So far, the existing studies dont find a significant increase in psychiatric adverse events compared to placebo
The maximum dose is 15 mg
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In contrast, when discussing tirzepatide vs retatrutide, it is notable that retatrutide is a novel triple agonist that activates GLP-1, GIP, and glucagon receptors
These typically occur in 20-40% of patients and include: Nausea (most common, especially during dose increases) Vomiting Diarrhea Stomach pain Decreased appetite Constipation These side effects usually improve over time as your body adjusts to the medication
We also report that 13% of patients with type 1 diabetes in our registry use adjuvant glucose-lowering therapy in addition to insulin, significantly higher than the 5.4% reported from the T1D Exchange Registry in the US [18]