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Kosolcharoen T, Nappi J, Peduzzi P, and et al
Role of diet in hyperuricemia and gout
Although these agents offer transformative therapeutic potential, their optimal use requires individualized care, careful patient selection, and ongoing safety surveillance
The rare scenario where faster escalation might make sense is someone who has been on a comparable dose of another incretin therapy and already has established GI tolerance to receptor agonists
Rosenstock J, Fras JP, Rodbard HW, Tof S, Sears E, Huh R, et al
In pre- and postnatal development studies in pregnant rats, empagliflozin was administered from gestation day 6 through to lactation day 20 (weaning) at up to 100 mg/kg/day (approximately 16-times the 25 mg maximum clinical dose) without maternal toxicity
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