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Among adolescents aged 1217 years with obesity, prescription use increased from 0.1 percent in 2020 to 0.5 percent in 2023, representing a relative rise of more than 300 percent, although total usage remains below 1 percent
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Metabolic surgery represents the most effective intervention for severe obesity and often produces diabetes remission
GLP-1 medications are contraindicated for patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
adding GIP agonism appears to further enhance the appetite and metabolic effect
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