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The SURMOUNT trials demonstrated tirzepatide at 15 mg achieving 15% to 21% body weight loss by week 72, about 17 months

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But the doses involved are 1000-3000 mg daily, far exceeding the 2 mg in compounded semaglutide injections

A responder analysis found about 65% of children on leucovorin had a notable language improvement , versus only 24% on placebo