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Abbreviations AMPK: AMP-activated protein kinase AHA: Alpha hydroxy acids BDMC: Bis-demethoxy curcumin CS: Chitosan COX-2: Cyclooxygenase-2 CIA: Collagen-induced arthritis Cur-EtE: Curcumin-ethyl ester Cur-Glc: Curcumin monoglucoside Cur-NPs: Curcumin nanoparticles CYP7A1: Cholesterol 7 alpha-hydroxylase DMC: Demethoxycurcumin ECM: Extracellular matrix FTIR spectroscopy: Fourier transform infrared spectroscopy Gel@Cur: Gelation-curcumin GPx: Glutathione peroxidase GelMA: Gelatin methacryloyl GLUT2: Glucose transporter 2 HSP70: Heat shock protein 70 IL: Interleukin JAK/STAT: Janus kinase and signal transducer and activator of transcription LOX: Lipoxygenase LDPE: Low-density polyethylene MMP: Matrix metalloproteinases MAPK: Mitogen-activated protein kinase MPEG-PCL: Methoxy poly(ethylene glycol)-poly(-caprolactone) mTOR: Mammalian target of rapamycin NF-B: Nuclear Factor kappa-light References Abdel-Mageed HM, AbuelEzz NZ, Ali AA, Abdelaziz AE, Nada D, Abdelraouf SM, Fouad SA, Bishr A, Radwan RA (2025) Newly designed curcumin-loaded hybrid nanoparticles: a multifunctional strategy for combating oxidative stress, inflammation, and infections to accelerate wound healing and tissue regeneration

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In hippocampal neuron cultures, Dihexa was reported to induce spinogenesis and synaptogenesis at picomolar concentrations the basis for the widely-cited seven orders of magnitude more potent than BDNF potency figure

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Some autistic children may be overwhelmed by typical classroom environments, while others may seek additional sensory input to focus effectively