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Of note, in the SURPASS-4 trial, adjudicated major adverse cardiovascular events (MACE) were not increased with tirzepatide compared with insulin glargine over an extended follow-up period of 52 additional weeks after the main trial period of 52 weeks [21]

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1 Introduction Syndromes of lipodystrophy are rare disorders where reduced adipose mass or adipose tissue dysfunction leads to metabolic disease

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