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The most frequently reported side effects were gastrointestinal problems such as nausea, vomiting, and diarrhoea, which were mainly mild to moderate and temporary

The Endocrine Societys guideline on pharmacological management of obesity recommends that diet, exercise, and behavioral modification be part of all obesity management approaches, with medications as add-ons when criteria are met

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Copper peptide cream 70% response rate, vitamin C 50%, tretinoin (retinoic acid) 40%