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After several months of consistent treatment, blood tests often show lower homocysteine

JAMA Otolaryngology Head & Neck Surgery, 131 (11), 970-975

When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases

Reduce Ongoing Liver Stress Alcohol, unnecessary supplements, contaminated products, excessive acetaminophen and medication interactions should be reviewed

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Side Effects: Generally well-tolerated