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Meanwhile, overall aging indicators were significantly improved: locomotor activity and endurance were enhanced, hair gloss increased, levels of aging-related inflammatory factors (such as TNF-, IL-6) decreased, and the average lifespan of mice was prolonged

It was developed in the 1990s by researchers at Monash University in Melbourne, Australia, with one goal: isolate the fat-burning portion of growth hormone and deliver those effects without the risks that come with full hGH administration

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the most common were dry mouth and insomnia. Astrup et al., The Lancet Who Should Avoid Tesofensine Individuals with uncontrolled hypertension or cardiovascular disease Anyone on SSRIs, SNRIs, or MAO inhibitors (risk of serotonin syndrome) Those with a history of severe anxiety, panic disorder, or arrhythmias Pregnant or breastfeeding women (due to lack of safety data) Best Practices for Safety Start at 0.25 mg/day and gradually titrate Avoid stacking with caffeine , yohimbine , or stim-heavy pre-workouts Monitor blood pressure, heart rate, and sleep quality Discontinue use if side effects worsen or persist beyond the adaptation period (710 days) Although Tesofensine has a relatively clean side effect profile at moderate doses, its still a powerful central agent