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This concept is supported by the finding that the glucagonostatic effect (i.e
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Li Y, Sun W, Han S, Li J, Ding S, Wang W, Yin Y (2016) IGF-1-involved negative feedback of NR2B NMDA subunits protects cultured hippocampal neurons against NMDA-induced excitotoxicity
Moreover, protein is generally more satiating than other macronutrients, as it promotes the release of satiety hormones like cholecystokinin, peptide YY, and GLP-1 [90]
Heres what helped me shift that thinking: Eat with smaller utensils or bowls
The different ones GI discontinuation rate: 5.6% of semaglutide (Wegovy) users stopped due to GI side effects, vs 2.7% of Tirzepatide (Mounjaro) users Diarrhoea: Common with Mounjaro because of its dual action Nausea and constipation: Seen more in Wegovy MHRA NAION warning (February 2026) : Both medications carry an updated warning about a very rare but serious eye condition (non-arteritic anterior ischaemic optic neuropathy)
A daily pill form of Wegovy was also approved by the FDA and made available on Jan
