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This may include things like weight and body condition management, exercise control, home environment alterations, joint supplements, herbal treatments, rehabilitation/physiotherapy, laser therapy, hydrotherapy, acupuncture, medication (such as NSAIDs, Opioids, Gabapentin, Ketamine, Paracetamol and others), shockwave treatment, intra-articular injections, stem cell therapy and even surgery
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GLP-1 RAs have positive effects on the prevention of cardiovascular mortality
However, Vpr also possesses DDR-inhibitory properties, antagonizing essential DSB repair mechanisms like HR and NHEJ 100