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10.1016/j.jstrokecerebrovasdis.2022.106605 288
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These genes, encompassing both risk-associated genes for sporadic PD (e.g., SNCA , LRRK2 , GBA ) and those associated with familial forms (e.g., PARK2 , PINK1 , PARK7 ), predominantly encode proteins involved in critical cellular functions like oxidative stress response, mitochondrial quality control, and protein degradation pathways
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Three distinct clinical entities have been described
