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In PsO, clinical studies evaluating GLP-1RAs such as liraglutide and semaglutide have reported significant improvements in PASI scores and histopathological skin features, effects that appear to be at least partially independent of weight loss ( Given the prominent role of IL-17driven inflammation in obese PsA patients, GLP-1RAs may also enhance the efficacy of biologic agents targeting these pathways

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doi: 10.1016/j.jcrc.2014.05.021 43 MicallefJ.SoeiroT.Jonville-BraA

Engineering precision nanoparticles for drug delivery

Structure compensates somewhat for reduced internal satiety signals